News

March 17, 2015
FLI-Ausbildung präsentiert sich beim 22. Berufsinformationsmarkt in Jena » more

February 12, 2015
23. April 2015 - "Forsche Schüler Tag" am FLI » more

December 9, 2014
Fritz-Boege-Vortragspreis für Ronny Hänold » more

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Press Releases

March 25, 2015
Notch-Code geknackt: Epigenetischer Kontrollmechanismus für entwicklungsbiologischen Signalweg entdeckt (Uni Ulm) » more

March 23, 2015
„Zuckersüße Bindungspartner“ regulieren Alzheimer-Proteine » more

March 19, 2015
Deutscher Krebspreis 2015 verliehen - Prof. Günter Klöppel, Prof. Wolfgang Wick und Prof. Karl Lenhard Rudolph wurden für ihre wegweisenden Arbeiten in der Onkologie ausgezeichnet (DKG) » more

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Our Mission

Human ageing is a multifactorial process controlled by both environmental and genetic factors. Our mission is to understand the molecular mechanisms that underlie the ageing process and that lead to age-related diseases. We hope that eventually this knowledge can contribute to a more healthy ageing of people. The central question we are aiming at answering is

 

«What are the molecular mechanisms and genetic factors contributing to the evolution of cellular and organismal dysfunction during human aging?».

 


 

Recent Selected Publications


Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes
Dahms SO, Mayer MC, Roeser D, Multhaup G, Than ME
Acta Crystallogr D Biol Crystallogr. 2015, 71, 494-504 [PubMed]

 

Merlin's wizardry guides cohesive migration
Zoch A, Morrison H.
Nat Cell Biol. 2015, 17, 212-213 [PubMed]

 

Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage
Tao S, Tang D, Morita Y, Sperka T, Omrani O, Lechel A, Sakk V, Kraus J, Kestler HA, Kühl M*, Rudolph KL*
EMBO J. 2015 (epub ahead of print) [PubMed]

 

Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization
Eschbach J, von Einem B, Müller K, Bayer H, Scheffold A, Morrison BE, Rudolph KL, Thal DR, Witting A, Weydt P, Otto M, Fauler M, Liss B, McLean PJ, Spada AR, Ludolph AC, Weishaupt JH, Danzer KM.
Ann Neurol. 2015, 77, 15-32 [PubMed]

 

Integration of cistromic and transcriptomic analyses identifies Nphs2, Mafb, and Magi2 as Wilms' Tumor 1 target genes in podocyte differentiation and maintenance
Dong L, Pietsch S, Tan Z, Perner B, Sierig R, Kruspe D, Groth M, Witzgall R, Gröne H, Platzer M, Englert C
J Am Soc Nephrol. 2015 (epub ahead of print) [PubMed]

 

» Overview Publications