Our Mission
Professor K. Lenhard Rudolph, FLI's new Scientific Director, will add to the institute's focus with his research on cell ageing. The latest findings of his research group lead to the identification of a mechanism that causes the loss of stem cells of the immune system during ageing. These results have been published as a cover article in the renowned journal CELL (Cell. 2012, 148, 1001-1014. [PubMed]).In order to further develop the institute's focal points Stem Cell Ageing, Genome Integrity and Systems Biology, new junior and senior groups with additional expertise are to be recruited.
Recent Selected Publications
Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal
Zarse K, Schmeisser S, Groth M, Priebe S, Beuster G, Kuhlow D, Guthke R, Platzer M, Kahn CR, Ristow M
Cell Metab. 2012, 15, 451-465 Journal
Fungal-induced cell cycle impairment, chromosome instability and apoptosis via differential activation of NF-κB
Ben-Abdallah M, Sturny-Leclère A, Avé P, Louise A, Moyrand F, Weih F, Janbon G, Mémet S
PLoS Pathog. 2012, 8, e1002555 [PubMed]
Structurally diverse μ-conotoxin PIIIA isomers block sodium channel NaV1.4
Tietze AA, Tietze D, Ohlenschläger O, Leipold E, Ullrich F, Kühl T, Mischo A, Buntkowsky G, Görlach M, Heinemann SH, Imhof D
Angew Chem Int Ed Engl. 2012, 51, 4058-4061 [PubMed]
Disrupted-in-schizophrenia 1 (DISC1) is necessary for the correct migration of cortical interneurons
Steinecke A, Gampe C, Valkova C, Kaether C, Bolz J
J Neurosci 2012, 32, 738-745 [PubMed]
Structural basis of β-amyloid-dependent synaptic dysfunctions
Haupt C, Leppert J, Rönicke R, Meinhardt J, Yadav JK, Ramachandran R, Ohlenschläger O, Reymann KG, Görlach M, Fändrich M.
Angew Chem Int Ed Engl. 2012, 51, 1576-1579 [PubMed]
