Human ageing is a multifactorial process controlled by both environmental and genetic factors. Our mission is to understand the molecular mechanisms that underlie the ageing process and that lead to age-related diseases. We hope that eventually this knowledge can contribute to a more healthy ageing of people. The central question we are aiming at answering is

«What are the mechanisms that induce senescence or that cause the development of diseases related to age?».

Recent Selected Publications

Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein
Dahms SO, Hoefgen S, Roeser D, Schlott B, Gührs KH, Than ME
Proc Natl Acad Sci 2010 (epub ahead of print)

 

Wt1 and Retinoic Acid Signaling in the Subcoelomic Mesenchyme Control the Development of the Pleuropericardial Membranes and the Sinus Horns
Norden J, Grieskamp T, Lausch E, van Wijk B, van den Hoff MJB, Englert C, Petry M, Mommersteeg MTM, Christoffels VM, Niederreither K, Kispert A
Circulation Research 2010 (epub ahead of print)

 

Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizer-like cells upon combined TNFR1/LTβR NF-κB signaling
Lötzer K, Döpping S, Connert S, Gräbner R, Spanbroek R, Lemser B, Beer M, Hildner M, Hehlgans T, van der Wall M, Mebius RE, Lovas A, Randolph GJ, Weih F*, Habenicht AJR *
Arterioscler Thromb Vasc Biol 2009, 30, 395-402 *equal contribution

 

Increased skeletal VEGF enhances β-catenin activity and results in excessively ossified bones
Maes C, Goossens S, Bartunkova S, Drogat B, Coenegrachts L, Stockmans I, Moermans K , Nyabi O, Haigh K , Naessens M, Haenebalcke L, Tuckermann JP, Tjwa M, Carmeliet P, Mandic V, David J-P, Behrens A, Nagy A, Carmeliet G, Haigh JJ
EMBO Journal 2010, 29, 424-41

 

Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity.
Friedrich RP, Tepper K, Rönicke R, Soom M, Westermann M, Reymann K, Kaether C, Fändrich M
Proc.Natl.Acad.Sci.USA 2010, epub ahead of print January 19

 

» Overview Publications