News

December 9, 2014
Fritz-Boege-Vortragspreis für Ronny Hänold » more

December 5, 2014
Bester Vortrag von Abinaya Nathan » more

September 25, 2014
Schüler der Jenaplan-Schule am FLI » more

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Press Releases

January 26, 2015
Krebs und Organversagen im Alter: Wnt-Aktivität reguliert Überleben von Stammzellen bei DNA-Schäden » more

January 22, 2015
Aus dem Gleichgewicht: Auch Inaktivierung des Onkogens Ras ist schädlich » more

January 5, 2015
Transkriptionsfaktor WT1 reguliert Nieren-Krankheitsgene » more

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Our Mission

Human ageing is a multifactorial process controlled by both environmental and genetic factors. Our mission is to understand the molecular mechanisms that underlie the ageing process and that lead to age-related diseases. We hope that eventually this knowledge can contribute to a more healthy ageing of people. The central question we are aiming at answering is

 

«What are the molecular mechanisms and genetic factors contributing to the evolution of cellular and organismal dysfunction during human aging?».

 


 

Recent Selected Publications


Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage
Tao S, Tang D, Morita Y, Sperka T, Omrani O, Lechel A, Sakk V, Kraus J, Kestler HA, Kühl M*, Rudolph KL*
EMBO J. 2015 (epub ahead of print) [PubMed]

 

Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization
Eschbach J, von Einem B, Müller K, Bayer H, Scheffold A, Morrison BE, Rudolph KL, Thal DR, Witting A, Weydt P, Otto M, Fauler M, Liss B, McLean PJ, Spada AR, Ludolph AC, Weishaupt JH, Danzer KM.
Ann Neurol. 2015, 77, 15-32 [PubMed]

 

Integration of cistromic and transcriptomic analyses identifies Nphs2, Mafb, and Magi2 as Wilms' Tumor 1 target genes in podocyte differentiation and maintenance
Dong L, Pietsch S, Tan Z, Perner B, Sierig R, Kruspe D, Groth M, Witzgall R, Gröne H, Platzer M, Englert C
J Am Soc Nephrol. 2015 (epub ahead of print) [PubMed]

 

Quantitative dissection and modeling of the NF-κB p100-p105 module reveals interdependent precursor proteolysis
Yılmaz ZB, Kofahl B, Beaudette P, Baum K, Ipenberg I, Weih F, Wolf J, Dittmar G, Scheidereit C
Cell Rep. 2014, 9, 1756-1769 [PubMed]

 

The intrinsically disordered amino-terminal region of human RecQL4: multiple DNA-binding domains confer annealing, strand exchange and G4 DNA binding
Keller H, Kiosze K, Sachsenweger J, Haumann S, Ohlenschläger O, Nuutinen T, Syväoja JE, Görlach M, Grosse F, Pospiech H
Nucleic Acids Res. 2014, 42, 12614-12627 [PubMed]

 

» Overview Publications