Life expectancy in Diabetes 2

Major statements are

i) From ageing research, information is coming that diabetes 2 may, in some cases, be beneficial  Poster

ii) The effects of blood pressure, HBA1c and cholesterin can be quantified by a simple formula  Report

Gene expression in colon cancer (in cooperation with the Inst.of Nutrition Research, FSU Jena)

Franziska Jahns, Anne Wilhelm, Michael Glei, Maria Radeva
with the technical help of Gabriele Günther and Silke Schulz

These are studies using human primary tissue, obtained from the University Hospital Jena (Dr. H. Mothes) after colon cancer surgery.

Major statements are

i) The  Defensin A6  gene is heavily overexpressed in adenoma.
This overexpression is reverted almost completely during progression to fully blown colon carcinoma   2010 BMC Cancer 10: 588

ii) Predictions derived from NIH's database dbEST agree well with data obtained from human individuals  2008 Curr Pharm Biot 9 509 - 514

iii) Gene expression, as determined by quantitative real time PCR, does often, but not always reflect protein expression, as determined by quantitative Western blots

iv) The expression of the housekeeping genes ß-actin and GUS are extremely stable at ages from 53 to 85




Combined gene – and protein expression analysis of tissues from individual colorectal cancer patients   Poster 
Multiprotein analysis using quantitative Western blots    Teaching text


Former subject on which the present work is based on    Protein-chip technology    ESF Exploratory Workshop: Protein Arrays: Bridging the gap between Physics and Biomedicine

HOME