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Publications


2011

Chakraborty P, Grosse F.
Human DHX9 helicase preferentially unwinds RNA-containing displacement loops (R-loops) and G-quadruplexes.
DNA Repair (Amst). 2011 May 9; [epub ahead of print].

2010

Gührs KH, Groth M, Grosse F.
A label-free assay of exonuclease activity using a pyrosequencing technique.
Anal Biochem. 2010 Oct 1;405(1):11-8.

Jain A, Bacolla A, Chakraborty P, Grosse F, Vasquez KM.
Human DHX9 helicase unwinds triple-helical DNA structures.
Biochemistry. 2010 Aug 24;49(33):6992-9

Chakraborty P, Grosse F.
WRN helicase unwinds Okazaki fragment-like hybrids in a reaction stimulated by the human DHX9 helicase.
Nucleic Acids Res. 2010 Aug;38(14):4722-30

Chinali A, Vater W, Rudakoff B, Sponner A, Unger E, Grosse F, Guehrs KH, Weisshart K.
Containment of extended length polymorphisms in silk proteins.
J Mol Evol. 2010 Apr;70(4):325-38.

Baum N, Schiene-Fischer C, Frost M, Schumann M, Sabapathy K, Ohlenschläger O, Grosse F, Schlott B.
The prolyl cis/trans isomerase cyclophilin 18 interacts with the tumor suppressor p53 and modifies its functions in cell cycle regulation and apoptosis.
Oncogene. 2009 Nov 5;28(44):3915-25.

2009

Blättel V, Wirth K, Claus H, Schlott B, Pfeiffer P, König H.
A lytic enzyme cocktail from Streptomyces sp. B578 for the control of lactic and acetic acid bacteria in wine.
Appl Microbiol Biotechnol. 2009 Jul;83(5):839-48.

Schilhabel A, Studenik S, Vödisch M, Kreher S, Schlott B, Pierik AJ, Diekert G.
The ether-cleaving methyltransferase system of the strict anaerobe Acetobacterium dehalogenans: analysis and expression of the encoding genes.
J Bacteriol. 2009 Jan;191(2):588-99. (Erratum in: J Bacteriol. 2009 Mar;191(6):1994: Pierik, Antonio Y corrected to Pierik, Antonio J)

Lehmann K, Müller JP, Schlott B, Skroblin P, Barz D, Norgauer J, Wetzker R.
PI3Kgamma controls oxidative bursts in neutrophils via interactions with PKCalpha and p47phox.
Biochem J. 2009 May 1;419(3):603-10.

Krämer OH, Knauer SK, Greiner G, Jandt E, Reichardt S, Gührs KH, Stauber RH, Böhmer FD, Heinzel T.
A phosphorylation-acetylation switch regulates STAT1 signaling.
Genes Dev. 2009 Jan 15;23(2):223-35.

2008

Gührs, K.-H., Schlott, B., Große, F., Weisshart, K.
Environmental conditions impinge on dragline silk composition.
Insect Mol Biol. 2008 Sep;17(5):553-64.

Schmidt U, Wollmann Y, Franke C, Grosse F, Saluz HP, Hänel F.
Characterization of the interaction between the human DNA topoisomerase IIbeta-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein.
Biochem J. 2008 Jan 1;409(1):169-77.

2007

Sponner A, Vater W, Monajembashi S, Unger E, Grosse F, Weisshart K.
Composition and hierarchical organisation of a spider silk.
PLoS ONE. 2007 Oct 3;2(10):e998.

Ping L, Büchler R, Mithöfer A, Svatos A, Spiteller D, Dettner K, Gmeiner S, Piel J, Schlott B, Boland W.
A novel Dps-type protein from insect gut bacteria catalyses hydrolysis and synthesis of N-acyl amino acids.
Environ Microbiol. 2007 Jun;9(6):1572-83.

Pollok S, Grosse F.
Cdc45 degradation during differentiation and apoptosis.
Biochem Biophys Res Commun. 2007 Nov 3;362(4):910-5.

Taneja P, Boche I, Hartmann H, Nasheuer HP, Grosse F, Fanning E, Weisshart K.
Different activities of the largest subunit of replication protein A cooperate during SV40 DNA replication.
FEBS Lett. 2007 Aug 21;581(21):3973-8.

Taneja P, Nasheuer HP, Hartmann H, Grosse F, Fanning E, Weisshart K.
Timed interactions between viral and cellular replication factors during the initiation of SV40 in vitro DNA replication.
Biochem J. 2007 Oct 15;407(2):313-20.

Pollok S, Bauerschmidt C, Sänger J, Nasheuer HP, Grosse F.
Human Cdc45 is a proliferation-associated antigen.
FEBS J. 2007 Jul;274(14):3669-84. Epub 2007 Jul 3.

Bauerschmidt C, Pollok S, Kremmer E, Nasheuer HP, Grosse F.
Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase.
Genes Cells. 2007 Jun;12(6):745-58.

Rockstroh A, Kleinert A, Kramer M, Grosse F, Søe K.
Cellular stress triggers the human topoisomerase I damage response independently of DNA damage in a p53 controlled manner.
Oncogene. 2007 Jan 4;26(1):123-31.

Zhang S, Hemmerich P, Grosse F.
Werner syndrome helicase (WRN), nuclear DNA helicase II (NDH II) and histone gammaH2AX are localized to the centrosome.
Cell Biol Int. 2007 Oct;31(10):1109-21.

Zhang S, Hemmerich P, Grosse F.
Centrosomal localization of DNA damage checkpoint proteins.
J Cell Biochem. 2007 May 15;101(2):451-65.

2006

Søe K, Hartung S, Grosse F.
Human topoisomerase I forms double cleavage complexes on natural DNA.
Biochem Biophys Res Commun. 2006 Oct 13;349(1):178-85.

Siddiqui RA, Hoischen C, Holst O, Heinze I, Schlott B, Gumpert J, Diekmann S, Grosse F, Platzer M.
The analysis of cell division and cell wall synthesis genes reveals mutationally inactivated ftsQ and mraY in a protoplast-type L-form of Escherichia coli.
FEMS Microbiol Lett. 2006 May;258(2):305-11.

Hammer M, Richter S, Guehrs KH, Schweitzer D.
Retinal pigment epithelium cell damage by A2-E and its photo-derivatives.
Mol Vis. 2006 Nov 1;12:1348-54.

2005

Sponner A, Vater W, Rommerskirch W, Vollrath F, Unger E, Grosse F, Weisshart K.
The conserved C-termini contribute to the properties of spider silk fibroins.
Biochem Biophys Res Commun. 2005 Dec 16;338(2):897-902.

Sponner A, Unger E, Grosse F, Weisshart K.
Differential polymerization of the two main protein components of dragline silk during fibre spinning.
Nat Mater. 2005 Oct;4(10):772-5.

Friedemann J, Grosse F, Zhang S.
Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity.
J Biol Chem. 2005 Sep 2;280(35):31303-13. Epub 2005 Jul 1.

Sponner A, Schlott B, Vollrath F, Unger E, Grosse F, Weisshart K.
Characterization of the protein components of Nephila clavipes dragline silk.
Biochemistry. 2005 Mar 29;44(12):4727-36.

Claus H, Akça E, Debaerdemaeker T, Evrard C, Declercq JP, Harris JR, Schlott B, König H.
Molecular organization of selected prokaryotic S-layer proteins.
Can J Microbiol. 2005 Sep;51(9):731-43. Review.

Christopeit T, Hortschansky P, Schroeckh V, Gührs K, Zandomeneghi G, Fändrich M.
Mutagenic analysis of the nucleation propensity of oxidized Alzheimer's beta-amyloid peptide.
Protein Sci. 2005 Aug;14(8):2125-31.

Gerlach D, Schlott B, Zähringer U, Schmidt KH.
N-acetyl-D-galactosamine/N-acetyl-D-glucosamine--recognizing lectin from the snail Cepaea hortensis: purification, chemical characterization, cloning and expression in E. coli.
FEMS Immunol Med Microbiol. 2005 Feb 1;43(2):223-32.

Mischo HE, Hemmerich P, Grosse F, Zhang S.
Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II.
J Biol Chem. 2005 Mar 11;280(10):9586-94.

2004

Horke S, Reumann K, Schulze C, Grosse F, Heise T.
The La-motif and the RRMs of hLa contribute individually to RNA recognition and subcellular localization.
J Biol Chem. Nov 26;279(48):50302-9.

Ehlers I, Horke S, Reumann K, Rang A, Grosse F, Will H, Heise T.
Functional characterization of the interaction between human La and hepatitis B virus RNA.
J Biol Chem. 2004 Oct 15;279(42):43437-43447. Epub 2004 Aug 9.

Zhang S, Hemmerich P, Grosse F.
Nucleolar localization of the human telomeric repeat binding factor 2 (TRF2).
J Cell Sci. 2004 Sep 1;117(Pt 17):3935-45.

Weisshart K, Friedl S, Taneja P, Nasheuer HP, Schlott B, Grosse F, Fanning E.
Partial proteolysis of SV40 T antigen reveals intramolecular contacts between domains and conformation changes upon hexamer assembly.
J Biol Chem. 2004 Sep 10;279(37):38943-38951.

Gerlach D, Schlott B, Schmidt KH.
Cloning and expression of a sialic acid-binding lectin from the snail Cepaea hortensis.
FEMS Immunol Med Microbiol. 2004 Apr 9;40(3):215-221.

Rudeschko O, Machnik A, Dörfelt H, Kaatz HH, Schlott B, Kinne RW.
A novel inhalation allergen present in the working environment of beekeepers.
Allergy. 2004 Mar;59(3):332-337.

Carella M, Ramachandran R, Schlott B, Leppert J, Glusa E, Ohlenschläger O.
(1)H, (13)C and (15)N sequence-specific resonance assignments of the two-domain thrombin inhibitor dipetalin.
J Biomol NMR. 2004 Nov; 30(3):383-384.

Zhang S, Grosse F.
Multiple functions of nuclear DNA helicase II (RNA helicase A) in nucleic acid metabolism.
Acta Biochim Biophys Sin (Shanghai). 2004 Mar;36(3):177-83. Review.

Sponner A, Unger E, Grosse F, Weisshart K.
Conserved C-termini of Spidroins Are Secreted by the Major Ampullate Glands and Retained in the Silk thread.
Biomacromolecules. 2004 May-Jun;5(3):840-845.

Soe K, Rockstroh, Schache P, Grosse F.
The human topoisomerase I damage response plays a role in apoptosis.
DNA Repair (Amst). 2004 Apr 1;3(4):387-93.
PMID: 15010314 [PubMed - indexed for MEDLINE]

Zhang S, Koehler C, Hemmerich P, Grosse F.
Nuclear DNA helicase II (RNA helicase A) binds to an F-actin containing shell that surrounds the nucleolus.
Exp. Cell Res. 2004 Feb 15;293(2):248-258.

Zhang S, Schlott B, Görlach M, Grosse F.
DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner.
Nucleic Acids Res. 2004, Jan 2; 32(1): 1-10.

2003

Afonin S, Glaser RW, Berditchevskaia M, Wadhwani P, Gührs KH, Mollmann U, Perner A, Ulrich AS.
4-Fluorophenylglycine as a Label for 19F NMR Structure Analysis of Membrane-Associated Peptides.
Chembiochem. 2003, 4, 1151-1163.

Fahlbusch B, Rudeschko O, Schlott B, Henzgen M, Schlenvoigt G, Schubert H, Kinne RW.
Further characterization of IgE-binding antigens from guinea pig hair as new members of the lipocalin family.
Allergy. 2003, 58, 629-934.

Isken O, Grassmann CW, Sarisky RT, Kann M, Zhang S, Grosse F, Kao PN, Behrens SE.
Members of the NF90/NFAR protein group are involved in the life cycle of a positive-strand RNA virus.
EMBO J. 2003, 22, 5655-5665.

Pestryakov PE, Weisshart K, Schlott B, Khodyreva SN, Kremmer E, Grosse F, Lavrik OI, Nasheuer HP.
Human replication protein A. The C-terminal RPA70 and the central RPA32 domains are involved in the interactions with the 3'-end of a primer-template DNA.
J Biol Chem. 2003, 278, 17515-17524.

Smith RW, Nasheuer HP.
Initiation of JC virus DNA replication in vitro by human and mouse DNA polymerase alpha-primase.
Eur J Biochem. 2003, 270, 2030-2037.

Soe K, Grosse F.
p53 stimulates human topoisomerase I activity by modulating its DNA binding.
Nucleic Acids Res. 2003, 31, 6585-6592.

2002

Akca E, Claus H, Schultz N, Karbach G, Schlott B, Debaerdemaeker T, Declercq JP, König H.
Genes and derived amino acid sequences of S-layer proteins from mesophilic, thermophilic, and extremely thermophilic methanococci.
Extremophiles. 2002 , 6, 351-358.

Fahlbusch B, Rudeschko O, Szilagyi U, Schlott B, Henzgen M, Schlenvoigt G, Schubert H.
Purification and partial characterization of the major allergen, Cav p 1, from guinea pig Cavia porcellus.
Allergy. 2002, 57, 417-422.

Gerlach D, Wagner M, Schlott B, Zahringer U, Schmidt KH.
Chemical and physicochemical characterization of the sialic acid-specific lectin from Cepaea hortensis.
FEMS Microbiol Lett. 2002, 214, 61-68.

Icke C, Schlott B, Ohlenschläger O, Hartmann M, Gührs KH, Glusa E.
Fusion proteins with anticoagulant and fibrinolytic properties: functional studies and structural considerations.
Mol Pharmacol. 2002 , 62, 203-209.

Melle C, Nasheuer HP.
Physical and functional interactions of the tumor suppressor protein p53 and DNA polymerase alpha-primase.
Nucleic Acids Res. 2002, 30, 1493-1499.

Schlott B, Wohnert J, Icke C, Hartmann M, Ramachandran R, Gührs KH, Glusa E, Flemming J, Gorlach M, Grosse F, Ohlenschläger O.
Interaction of Kazal-type inhibitor domains with serine proteinases: biochemical and structural studies.
J Mol Biol. 2002, 318, 533-546.

Smith RW, Steffen C, Grosse F, Nasheuer HP.
Species specificity of simian virus 40 DNA replication in vitro requires multiple functions of human DNA polymerase alpha.
J Biol Chem. 2002, 277, 20541-20548.

Smith RW, Nasheuer HP.
Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180.
FEBS Lett. 2002, 527, 143-146.

Stephan H, Grosse F, Soe K.
Human topoisomerase I cleavage complexes are repaired by a p53-stimulated recombination-like reaction in vitro.
Nucleic Acids Res. 2002, 30, 5087-5093.

Zhang S, Buder K, Burkhardt C, Schlott B, Görlach M, Grosse F.
Nuclear DNA helicase II/RNA helicase A binds to filamentous actin.
J Biol Chem. 2002, 277, 843-853.

Reviews/Book chapters

Grosse F.
A dexter exo within p53.
Cell Cycle. 2010 Mar 15;9(6):1025-30.

Zhang S, Grosse F. Molecular characterization of nuclear DNA helicase II (RNA helicase A).
Methods Mol Biol. 2010;587:291-302. Pospiech H, Grosse F, Pisani F. The initiation step of eukaryotic DNA replication.
Genome Stability and Human Diseases; Subcellular Biochemistry, 2010, Volume 50, 79-104.

Pisani FM, De Felice M, De Falco M, Pollok S, Nasheuer HP.
Regulation of eukaryotic DNA replication at the initiation step.
DNA Replication, Repair and Recombination at the Crossroad Between Genome Integrity and Genome Instability: A Biochemical Perspective, 2008, 1-20, ISBN 978-81-308-0253-4.

Syväoja JE, Pospiech H.
The elongation phase of the eukaryotic DNA replication
DNA Replication, Repair and Recombination at the Crossroad Between Genome Integrity and Genome Instability: A Biochemical Perspective, 2008, 21-40, ISBN 978-81-308-0253-4

Grosse F.
Biologie der Alterungsprozesse.
Medizin des Alterns und des Alten Menschen
Querschnittsbereiche der Medizin, 2007, Huber-Verlag Bern. Book chapter.

Søe K, Rockstroh A, Grosse F.
A Role of Human Topoisomerase I in DNA Repair and Apoptosis.
Genome Dynamics and Stability, Springer, 2007. Book chapter.

Claus H, Akça E, Debaerdemaeker T, Evrard C, Declercq JP, Harris JR, Schlott B, König H.
Molecular organization of selected prokaryotic S-layer proteins.
Can J Microbiol. 2005 Sep;51(9):731-43. Review.

Zhang S, Grosse F.
Multiple functions of nuclear DNA helicase II (RNA helicase A) in nucleic acid metabolism.
Acta Biochim. Biophys. Sin (Shanghai). 2004, 36(3):177-83. Review.

Pollok S, Stoepel J, Bauerschmidt C, Kremmer E, Nasheuer H.
Regulation of eukaryotic DNA replication at the initiation step
Biochem Soc Trans. 2003, 31(Pt 1), 266-269. Review.

Nasheuer HP, Smith R, Bauerschmidt C, Grosse F, Weisshart K.
Initiation of eukaryotic DNA replication: regulation and mechanisms.
Prog Nucleic Acid Res Mol Biol. 2002, 72, 41-94. Review.