The flagship for fluorescence confocal analyses at the FLI is the LSM510-META/Confocor2 microscope from Zeiss. A variety of laser lines allows for detection and separation of most common fluorophores in fixed or living specimen to determine protein co-localization, interaction (FRET), and dynamics employing time-laps microscopy, bleaching techniques (FRAP), and fluorescence correlation spectroscopy (FCS). In addition, an ApoTome microscope for high resolution fluorescence microscopy is on duty. The ApoTome is based on structured illumination and delivers quasi-confocal images.