The Nothobranchius Project
Research group Cellerino: Biology of aging
Identification of manipulations which lead to life-extension is a milestone towards understanding the biological mechanisms controlling longevity. Due to its short lifespan, Nothobranchius furzeri represent an ideal model system to investigate life-extension. Three different manipulations can retard aging in Nothobranchius furzeri
- Manipulations of environmental factors (e.g. temperature)
- Dietary supplementation with small molecules (e.g. resveratrol)
- Crossing with longer-lived isolates/subspecies
Aim of the group is to identify other life-extending manipulations, to test the effects of small molecules on longevity and age-related markers and to provide a phenotyping platform to dissect the genetic components controlling differences in aging phenotype in different isolates of N .furzeri.
Last update: March 7, 2008
