Age-associated diseases(Zur Zeit nur in Englisch verfügbar)
Impaired tissue homeostasis
Ageing is affecting all organs. Understanding of organ development, maintenance and homeostasis is therefore highly relevant for the ageing process and concomitant diseases.
- Ageing-related bone metabolism (Tuckermann)
influence and mechanism of glucocorticoids, estrogen and growth hormones on osteoporosis using mouse models, ChIP-on-chip screens and genome-wide siRNA technology
- Genetic predisposition (Platzer)
to chronic inflammation
- Glucocorticoid induced osteoporosis (Tuckermann)
Using cell type specific and function selective mutant mice of the glucocorticoid receptor we dissect the relevant cell type and molecular mechanism involved in glucorticoid induced osteoporosis, a major complication of steroid therapy.
- Kidney development (Englert)
role of WT1 in kidney development and homeostasis
- Lymphoid organ development (Weih)
role of NF-κB transcription factors in development and function of primary and secondary lymphoid tissues
- Regulation of the hematopoeitic niche by osteogenic hormones (Tuckermann)
During ageing an exhaustion of stem cell self-renewal and decrease of the capacity to maintain tissue homeostasis occurs and accelerate the ageing process and the onset of age related diseases. The so called stem cell niche residing in the bone supports the presence and function of hematopoietic stem cells. We investigate the influence of hormones acting on bone in their contribution to hematopoietic stem cell maintenance to understand the decay of stem cell numbers during ageing.