News

April 24, 2015
Neugierige Schüler » more

April 17, 2015
Wissenschaftspreis des Beutenberg-Campus Vereins an Dr. Dr. Alexander Schulz » more

March 21, 2015
4. Berliner Demografie Forum » more

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Press Releases

May 27, 2015
Stem Cells in Monastery Cells - FLI organizes top-class Else Kröner-Fresenius Symposium in Erice, Sicily » more

May 13, 2015
Denn das Leben bleibt bunt - Vernissage zur „Kunst am Bau“ im Leibniz‐Institut für Altersforschung » more

May 8, 2015
Thüringer Ministerpräsident hält Grußwort zum 1. Mitteldeutschen Demografie Forum (MDF) » more

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Our Mission

Human ageing is a multifactorial process controlled by both environmental and genetic factors. Our mission is to understand the molecular mechanisms that underlie the ageing process and that lead to age-related diseases. We hope that eventually this knowledge can contribute to a more healthy ageing of people. The central question we are aiming at answering is

 

«What are the molecular mechanisms and genetic factors contributing to the evolution of cellular and organismal dysfunction during human aging?».

 


 

Recent Selected Publications


From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology
Cellerino A, Valenzano DR, Reichard M
Biol Rev 2015 (epub ahead of print) [PubMed]

 

Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways
Chen Z, Yi W, Morita Y, Wang H, Cong Y, Liu JP, Xiao Z, Rudolph KL, Cheng T, Ju Z
Nat Commun. 2015, 6, 6808 [PubMed]

 

VEGFR2 signaling prevents colorectal cancer cell senescence to promote tumorigenesis in mice with colitis
Foersch S, Sperka T, Lindner C, Taut A, Rudolph KL, Breier G, Boxberger F, Rau TT, Hartmann A, Stürzl M, Wittkopf N, Haep L, Wirtz S, Neurath MF, Waldner MJ
Gastroenterology. 2015 (epub ahead of print) [PubMed]

 

Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response
Hein K, Mittler G, Cizelsky W, Kühl M, Ferrante F, Liefke R, Berger IM, Just S, Sträng JE, Kestler HA, Oswald F, Borggrefe T
Sci Signal. 2015, 8, ra30 [PubMed]

 

Structure and regulatory role of the C-terminal winged helix domain of the archaeal minichromosome maintenance complex
Wiedemann C, Szambowska A, Häfner S, Ohlenschläger O, Gührs KH, Görlach M
Nucleic Acids Res. 2015, 43, 2958-2967 [PubMed]

 

» Overview Publications