News

April 17, 2015
Wissenschaftspreis des Beutenberg-Campus Vereins an Dr. Dr. Alexander Schulz » more

March 17, 2015
FLI-Ausbildung präsentiert sich beim 22. Berufsinformationsmarkt in Jena » more

February 12, 2015
23. April 2015 - "Forsche Schüler Tag" am FLI » more

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Press Releases

April 16, 2015
Clemson makes international breakthrough for understanding aging process (Clemson University) » more

April 16, 2015
10 Jahre Noble Gespräche am Beutenberg - Nobelpreisträger Hartmut Michel spricht über das Thema "Vom Unsinn der Biokraftstoffe" (BBC) » more

April 10, 2015
Dr. Jekyll und Mr. Hyde: Telomerase in Stammzellen » more

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Our Mission

Human ageing is a multifactorial process controlled by both environmental and genetic factors. Our mission is to understand the molecular mechanisms that underlie the ageing process and that lead to age-related diseases. We hope that eventually this knowledge can contribute to a more healthy ageing of people. The central question we are aiming at answering is

 

«What are the molecular mechanisms and genetic factors contributing to the evolution of cellular and organismal dysfunction during human aging?».

 


 

Recent Selected Publications


Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways
Chen Z, Yi W, Morita Y, Wang H, Cong Y, Liu JP, Xiao Z, Rudolph KL, Cheng T, Ju Z
Nat Commun. 2015, 6, 6808 [PubMed]

 

VEGFR2 signaling prevents colorectal cancer cell senescence to promote tumorigenesis in mice with colitis
Foersch S, Sperka T, Lindner C, Taut A, Rudolph KL, Breier G, Boxberger F, Rau TT, Hartmann A, Stürzl M, Wittkopf N, Haep L, Wirtz S, Neurath MF, Waldner MJ
Gastroenterology. 2015 (epub ahead of print) [PubMed]

 

Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response
Hein K, Mittler G, Cizelsky W, Kühl M, Ferrante F, Liefke R, Berger IM, Just S, Sträng JE, Kestler HA, Oswald F, Borggrefe T
Sci Signal. 2015, 8, ra30 [PubMed]

 

Structure and regulatory role of the C-terminal winged helix domain of the archaeal minichromosome maintenance complex
Wiedemann C, Szambowska A, Häfner S, Ohlenschläger O, Gührs KH, Görlach M
Nucleic Acids Res. 2015, 43, 2958-2967 [PubMed]

 

Inhibition of wild-type p53-induced phosphatase 1 promotes liver regeneration in mice by direct activation of mammalian target of rapamycin
Zhang L, Liu L, He Z, Li G, Liu J, Song Z, Jin H, Rudolph KL, Yang H, Mao Y, Zhang L, Zhang H, Xiao Z, Ju Z
Hepatology. 2015 (epub ahead of print) [PubMed]

 

» Overview Publications