News

September 24, 2015
Herausforderungen in Zeiten des demografischen Wandels » more

July 28, 2015
Neues aus der Welt der Bioinformatik - FLI-Forschungsgruppe organisiert internationale Tagung „Statistical Computing“ auf Schloss Reisensburg » more

July 10, 2015
From Flies to Mammals » more

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Press Releases

July 29, 2015
Potential für Entwicklung zielgerichteter Tumortherapien - Verlust des ATM-Gens beschleunigt die Entstehung von Bauchspeicheldrüsenkrebs (Universitätsklinikum Ulm) » more

July 24, 2015
BILLY zu Gast beim Killi - Vorschulkinder der Kita BILLY bestaunen den Killifisch am FLI » more

July 23, 2015
Adding fuel helps fighting the fire - Cortisone affects Acute Lung Injury (ALI) via pro-inflammatory signalling pathways (Uni Ulm) » more

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Our Mission

Human ageing is a multifactorial process controlled by both environmental and genetic factors. Our mission is to understand the molecular mechanisms that underlie the ageing process and that lead to age-related diseases. We hope that eventually this knowledge can contribute to a more healthy ageing of people. The central question we are aiming at answering is

 

«What are the molecular mechanisms and genetic factors contributing to the evolution of cellular and organismal dysfunction during human aging?».

 


 

Recent Selected Publications


Loss of ATM accelerates pancreatic cancer formation and epithelial-mesenchymal transition
Russell R, Perkhofer L, Liebau S, Lin Q, Lechel A, Feld FM, Hessmann E, Gaedcke J, Güthle M, Zenke M, Hartmann D, von Figura G, Weissinger SE, Rudolph KL, Möller P, Lennerz JK, Seufferlein T, Wagner M, Kleger A
Nat Commun. 2015, 6, 7677 [PubMed]

 

Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1
Vettorazzi S, Bode C, Dejager L, Frappart L, Shelest E, Klaßen C, Tasdogan A, Reichardt HM, Libert C, Schneider M, Weih F, Henriette Uhlenhaut N, David JP, Gräler M, Kleiman A, Tuckermann JP
Nat Commun. 2015, 6, 7796 [PubMed]

 

Towards an understanding of kidney diseases associated with WT1 mutations
Dong L, Pietsch S, Englert C
Kidney Int. 2015 (epub ahead of print) [PubMed]

 

Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice
Hartmann K, Illing A, Leithäuser F, Baisantry A, Quintanilla-Fend L, Rudolph KL
Leukemia. 2015 (epub ahead of print) [PubMed]

 

Age-dependent decline in fin regenerative capacity in the short-lived fish Nothobranchius furzeri
Wendler S, Hartmann N, Hoppe B, Englert C
Aging Cell. 2015 (epub ahead of print) [PubMed]

 

» Overview Publications