News

September 25, 2014
Schüler der Jenaplan-Schule am FLI » more

September 15, 2014
2. Gesundheitstag am FLI » more

September 1, 2014
Lars Björn Riecken erhält FENS-IBRO Stipendium » more

  » Overview News


Press Releases

November 13, 2014
Diabetes ist die häufigste Alterskrankheit in Deutschland » more

October 27, 2014
Den Fragen des Alterns begegnen - Leibniz-Forschungsverbund Healthy Ageing veröffentlicht Expertenservice » more

October 20, 2014
Diabetes - Gehirn beeinflusst den Energie- und Stoffwechselhaushalt » more

  » Overview Press Releases


 

Our Mission

Human ageing is a multifactorial process controlled by both environmental and genetic factors. Our mission is to understand the molecular mechanisms that underlie the ageing process and that lead to age-related diseases. We hope that eventually this knowledge can contribute to a more healthy ageing of people. The central question we are aiming at answering is

 

«What are the molecular mechanisms and genetic factors contributing to the evolution of cellular and organismal dysfunction during human aging?».

 


Prof Falk Weih
We mourn the loss of

Professor Dr. Falk Weih

Falk Weih has significantly influenced the scientific focus of our institute. His most important scientific achievements lay in the delineation of molecular mechanisms which play a role in the development of the immune system as well as in the genesis of age-related immune deficiencies.
Professor Weih passed away on October 28, 2014.

Our deep sadness is mixed with memories of the sharp-witted, creative scientist and the supportive and wonderful person he has been. Encounters with him, his ideas and his humor will stay with us forever.

The whole staff of the institute will always feel much obliged to Falk Weih.

 

Recent Selected Publications


The intrinsically disordered amino-terminal region of human RecQL4: multiple DNA-binding domains confer annealing, strand exchange and G4 DNA binding
Keller H, Kiosze K, Sachsenweger J, Haumann S, Ohlenschläger O, Nuutinen T, Syväoja JE, Görlach M, Grosse F, Pospiech H
Nucleic Acids Res. 2014, (epub ahead of print) [PubMed]

 

p21 promotes sustained liver regeneration and hepatocarcinogenesis in chronic cholestatic liver injury
Marhenke S, Buitrago-Molina LE, Endig J, Orlik J, Schweitzer N, Klett S, Longerich T, Geffers R, Sánchez Muñoz A, Dorrell C, Katz SF, Lechel A, Weng H, Krech T, Lehmann U, Dooley S, Rudolph KL, Manns MP, Vogel A
Gut. 2014, 63, 1501-1512 [PubMed]

 

Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice
Missios P, Zhou Y, Guachalla LM, von Figura G, Wegner A, Chakkarappan SR, Binz T, Gompf A, Hartleben G, Burkhalter MD, Wulff V, Günes C, Sattler RW, Song Z, Illig T, Klaus S, Böhm BO, Wenz T, Hiller K, Rudolph KL
Nat Commun. 2014, 5, 4924 [PubMed]

 

Structure and Biomedical Applications of Amyloid Oligomer Nanoparticles
Kumar ST*, Meinhardt J*, Fuchs AK, Aumüller T, Leppert J, Büchele B, Knüpfer U, Ramachandran R, Yadav JK, Prell E, Morgado I, Ohlenschläger O, Horn U, Simmet T, Görlach M**, Fändrich M**
ACS Nano. 2014, (epub ahead of print) [PubMed]

 

Inhibition of JAK-STAT signaling stimulates adult satellite cell function
Price FD, von Maltzahn J, Bentzinger CF, Dumont NA, Yin H, Chang NC, Wilson DH, Frenette J, Rudnicki MA
Nat Med. 2014, 20, 1174-1181 [PubMed]

 

» Overview Publications