Human ageing is a multifactorial process controlled by both environmental and genetic factors. Our mission is to understand the molecular mechanisms that underlie the ageing process and that lead to age-related diseases. We hope that eventually this knowledge can contribute to a more healthy ageing of people. The central question we are aiming at answering is

«What are the mechanisms that induce senescence or that cause the development of diseases related to age?».

Recent Selected Publications

Thymus-derived glucocorticoids mediate androgen effects on thymocyte homeostasis
Chen Y, Qiao S, Tuckermann J, Okret S, Jondal M
FASEB J 2010 (epub ahead of print)

 

Merlin inhibits neurite outgrowth in the CNS
Schulz A, Geissler KJ, Kumar S, Leichsenring G, Morrison H*, Baader SL*
J Neurosci. 2010, 30, 10177-86 (*equal contribution)

 

Highly Modular Structure and Ligand Binding by Conformational Capture in a Minimalistic Riboswitch
Duchardt-Ferner E, Weigand JE, Ohlenschläger O, Schmidtke SR, Suess B, Wöhnert J
Angew Chem Int Ed Engl. 2010, 49, 6216-19

 

Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor
Rauch A, Seitz S, Baschant, U, Schilling AF, Illing A, Stride B, Kirilov M, Mandic V, Takacz A, Schmidt-Ullrich R, Ostermay S, Schinke T, Spanbroek R, Zaiss M, Angel PE, Lerner UH, David JP, Reichard HM, Amling M, Schütz G, Tuckermann J
Cell Metabolism 2010, 11, 517-531

 

Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein
Dahms SO, Hoefgen S, Roeser D, Schlott B, Gührs KH, Than ME
Proc Natl Acad Sci 2010, 107, 5381-5386

 

» Overview Publications