February 12, 2015
23. April 2015 - "Forsche Schüler Tag" am FLI » more

December 9, 2014
Fritz-Boege-Vortragspreis für Ronny Hänold » more

December 5, 2014
Bester Vortrag von Abinaya Nathan » more

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Press Releases

February 26, 2015
New resource for aging research: Genome of turquoise killifish publicly available as clone library » more

February 11, 2015
Was bedeutet Gesundes Altern? Wissenschaftler tagen auf interdisziplinärem Symposium in Mannheim » more

January 26, 2015
Krebs und Organversagen im Alter: Wnt-Aktivität reguliert Überleben von Stammzellen bei DNA-Schäden » more

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Our Mission

Human ageing is a multifactorial process controlled by both environmental and genetic factors. Our mission is to understand the molecular mechanisms that underlie the ageing process and that lead to age-related diseases. We hope that eventually this knowledge can contribute to a more healthy ageing of people. The central question we are aiming at answering is


«What are the molecular mechanisms and genetic factors contributing to the evolution of cellular and organismal dysfunction during human aging?».



Recent Selected Publications

Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage
Tao S, Tang D, Morita Y, Sperka T, Omrani O, Lechel A, Sakk V, Kraus J, Kestler HA, Kühl M*, Rudolph KL*
EMBO J. 2015 (epub ahead of print) [PubMed]


Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization
Eschbach J, von Einem B, Müller K, Bayer H, Scheffold A, Morrison BE, Rudolph KL, Thal DR, Witting A, Weydt P, Otto M, Fauler M, Liss B, McLean PJ, Spada AR, Ludolph AC, Weishaupt JH, Danzer KM.
Ann Neurol. 2015, 77, 15-32 [PubMed]


Integration of cistromic and transcriptomic analyses identifies Nphs2, Mafb, and Magi2 as Wilms' Tumor 1 target genes in podocyte differentiation and maintenance
Dong L, Pietsch S, Tan Z, Perner B, Sierig R, Kruspe D, Groth M, Witzgall R, Gröne H, Platzer M, Englert C
J Am Soc Nephrol. 2015 (epub ahead of print) [PubMed]


Quantitative dissection and modeling of the NF-κB p100-p105 module reveals interdependent precursor proteolysis
Yılmaz ZB, Kofahl B, Beaudette P, Baum K, Ipenberg I, Weih F, Wolf J, Dittmar G, Scheidereit C
Cell Rep. 2014, 9, 1756-1769 [PubMed]


The intrinsically disordered amino-terminal region of human RecQL4: multiple DNA-binding domains confer annealing, strand exchange and G4 DNA binding
Keller H, Kiosze K, Sachsenweger J, Haumann S, Ohlenschläger O, Nuutinen T, Syväoja JE, Görlach M, Grosse F, Pospiech H
Nucleic Acids Res. 2014, 42, 12614-12627 [PubMed]


» Overview Publications