Publikationen Jan Peter Tuckermann

    2012

  • Reichardt SD, Föller M, Rexhepaj R, Pathare G, Minnich K, Tuckermann JP, Lang F, Reichardt HM. Glucocorticoids enhance intestinal glucose uptake via the dimerized glucocorticoid receptor in enterocytes. Endocrinology. 2012 (epub ahead of print) [PubMed]
  • Kleiman A, Hübner S, Rodriguez Parkitna JM, Neumann A, Hofer S, Weigand MA, Bauer M, Schmid W, Schütz G, Libert C, Reichardt HM, Tuckermann JP. Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages. FASEB J. 2012, 26, 722-729 [PubMed]

    • 2011

  • Baschant U, Frappart L, Rauchhaus U, Bruns L, Reichardt HM, Kamradt T, Bräuer R, Tuckermann JP. Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells. Proc Natl Acad Sci USA. 2011, 108, 19317-19322 [PubMed] Evaluated by "Faculty of 1000"
  • Schweingruber N, Haine A, Tiede K, Karabinskaja A, van den Brandt J, Wüst S, Metselaar JM, Gold R, Tuckermann JP, Reichardt HM, Lühder F. Liposomal encapsulation of glucocorticoids alters their mode of action in the treatment of experimental autoimmune encephalomyelitis. J Immunol 2011, 187, 4310-4318 [PubMed]
  • Rose AJ, Díaz MB, Reimann A, Klement J, Walcher T, Krones-Herzig A, Strobel O, Werner J, Peters A, Kleyman A, Tuckermann JP, Vegiopoulos A, Herzig S. Molecular control of systemic bile acid homeostasis by the liver glucocorticoid receptor. Cell Metab. 2011, 14, 123-130 [PubMed]
  • Conaway HH, Pirhayati A, Persson E, Pettersson U, Svensson O, Lindholm C, Henning P, Tuckermann J, Lerner UH. Retinoids stimulate periosteal bone resorption by enhancing RANKL, a response inhibited by monomeric glucocorticoid receptor. J Biol Chem. 2011, 286, 31425-31436 [PubMed]
  • Van Bogaert T, Vandevyver S, Dejager L, Van Hauwermeiren F, Pinheiro I, Petta I, Engblom D, Kleyman A, Schutz G, Tuckermann J, Libert C. TNF inhibits glucocorticoid receptor function in mice: A strong signal towards lethal shock. J Biol Chem. 2011, 286, 26555-26567 [PubMed]
  • Rauner M, Goettsch C, Stein N, Thiele S, Bornhaeuser M, De Bosscher K, Haegeman G, Tuckermann J, Hofbauer LC. Dissociation of osteogenic and immunological effects by the selective glucocorticoid receptor agonist, compound A, in human bone marrow stromal cells. Endocrinology. 2011, 152, 103-112 [PubMed]
  • Luther J, Driessler F, Megges M, Hess A, Herbort B, Mandic V, Zaiss MM, Reichardt A, Zech C, Tuckermann JP, Calkhoven CF, Wagner EF, Schett G, David J-P. Elevated Fra-1 expression causes severe lipodystrophy. J Cell Sci. 2011, 124, 1465-1476 [PubMed]
  • Rauch A*, Gossye V*, Bracke D, Gevaert E, Jacques P, Van Beneden K, Vandooren B, Rauner M, Hofbauer LC, Haegeman G, Elewaut D, Tuckermann JP**, De Bosscher K**. An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation. FASEB J. 2011, 25, 1323-1332. (*,**equal contribution) [PubMed]
  • Schmieder A, Schledzewski K, Michel J, Tuckermann JP, Tome L, Sticht C, Gkaniatsou C, Nicolay JP, Demory A, Faulhaber J, Kzhyshkowska J, Géraud C, Goerdt S. Synergistic activation by p38MAPK and glucocorticoid signaling mediates induction of M2-like tumor-associated macrophages expressing the novel CD20 homolog MS4A8A. Int J Cancer. 2011, 129, 122-132 [PubMed]
  • Asada M*, Rauch A*, Shimizu H, Maruyama H, Miyaki S, Shibamori M, Kawasome H, Ishiyama H, Tuckermann JP**, Asahara H**. DNA binding-dependent glucocorticoid receptor activity promotes adipogenesis via Krüppel-like factor 15 gene expression. Lab Invest 2011, 91, 203-215 (*, **equal contribution) [PubMed]
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    2010

  • Chen Y, Qiao S, Tuckermann J, Okret S, Jondal M. Thymus-derived glucocorticoids mediate androgen effects on thymocyte homeostasis. FASEB J 2010, 24, 5043-5051 [PubMed]
  • Shalapour S, Deiser K, Sercan O, Tuckermann J, Minnich K, Willimsky G, Blankenstein T, Hämmerling GJ, Arnold B, Schüler T. Commensal microflora and interferon-gamma promote steady-state interleukin-7 production in vivo. Eur J Immunol 2010, 40, 2391-2400 [PubMed]
  • Tuckermann J, Bourguet W, Mandrup S. Meeting report: nuclear receptors: transcription factors and drug targets connecting basic research with translational medicine. Mol Endocrinol 2010, 24, 1311-1321 [PubMed]
  • Rauch A, Seitz S, Baschant, U, Schilling AF, Illing A, Stride B, Kirilov M, Mandic V, Takacz A, Schmidt-Ullrich R, Ostermay S, Schinke T, Spanbroek R, Zaiss M, Angel PE, Lerner UH, David JP, Reichard HM, Amling M, Schütz G, Tuckermann J. Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell Metab 2010, 11, 517-531 [PubMed]
  • Frijters R, Fleuren W, Toonen EJ, Tuckermann JP, Reichardt HM, Van der Maaden H, Van Elsas A, Van Lierop MJ, Dokter W, De Vlieg J, Alkema W. Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor. BMC Genomics 2010, 11, 359 [PubMed]
  • Baschant U, Tuckermann J. The role of the glucocorticoid receptor in inflammation and immunity. J Steroid Biochem Mol Biol. 2010, 120, 69-75 [PubMed]
  • Maes C, Goossens S, Bartunkova S, Drogat B, Coenegrachts L, Stockmans I, Moermans K , Nyabi O, Haigh K , Naessens M, Haenebalcke L, Tuckermann JP, Tjwa M, Carmeliet P, Mandic V, David J-P, Behrens A, Nagy A, Carmeliet G, Haigh JJ. Increased skeletal VEGF enhances β-catenin activity and results in excessively ossified bones. EMBO J. 2010, 29, 424-441 [PubMed]
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    2009

  • Wüst S, Tischner D, John M, Tuckermann JP, Menzfeld C, Hanisch UK, van den Brandt J, Luhder F, Reichardt HM. Therapeutic and adverse effects of a non-steroidal glucocorticoid receptor ligand in a mouse model of multiple sclerosis. PLoS One. 2009, 4, e8202 [PubMed]
  • Chichelnitskiy E, Vegiopoulos A, Berriel Diaz M, Ziegler A, Kleiman A, Rauch A, Tuckermann J, Herzig S. In vivo phosphoenolpyruvate carboxykinase promoter mapping identifies disrupted hormonal synergism as a target of inflammation during sepsis in mice. Hepatology. 2009, 50, 1963-1971 [PubMed]
  • Parlato R, Otto C, Tuckermann J, Stotz S, Kaden S, Gröne HJ, Unsicker K, Schütz G. Conditional inactivation of glucocorticoid receptor gene in dopamine-beta-hydroxylase cells impairs chromaffin cell survival. Endocrinology 2009, 150, 1775-1781 [PubMed]
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    2008

  • Hintzen C, Haan C, Tuckermann JP, Heinrich PC, Hermanns HM. Oncostatin M-induced and constitutive activation of the JAK2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression. J Immunol 2008, 181, 7341-7349 [PubMed]
  • Doni A, Mantovani G, Porta C, Tuckermann J, Reichardt HM, Kleiman A, Sironi M, Rubino L, Pasqualini F, Nebuloni M, Signorini S, Peri G, Sica A, Beck-Peccoz P, Bottazzi B, Mantovani A. Cell-specific regulation of PTX3 by glucocorticoid hormones in hematopoietic and nonhematopoietic cells. J Biol Chem 2008, 283, 29983-29992 [PubMed]
  • Preusch MR, Rattazzi M, Albrecht C, Merle U, Tuckermann J, Schütz G, Blessing E, Zoppellaro G, Pauletto P, Krempien R, Rosenfeld ME, Katus HA, Bea F. Critical role of macrophages in glucocorticoid driven vascular calcification in a mouse-model of atherosclerosis. Arterioscler Thromb Vasc Biol 2008, 28, 2158-2164 [PubMed]
  • Bayo P, Sanchis A, Bravo A, Cascallana JL, Buder K, Tuckermann J, Schütz G, Pérez P. Glucocorticoid receptor is required for skin barrier competence. Endocrinology 2008, 149, 1377-1388 [PubMed]
  • Wüst S, van den Brandt J, Tischner D, Kleiman A, Tuckermann JP, Gold R, Lühder F, Reichardt HM. Peripheral T cells are the therapeutic targets of glucocorticoids in experimental autoimmune encephalomyelitis. J Immunol 2008, 180, 8434-8443 [PubMed]

    2007

  • Textor B, Licht AH, Tuckermann JP, Jessberger R, Razin E, Angel P, Schorpp-Kistner M, Hartenstein B. JunB is required for IgE-mediated degranulation and cytokine release of mast cells. J Immunol 2007, 179, 6873-80 [PubMed]
  • Maier JV, Brema S, Tuckermann JP, Herzer U, Klein M, Stassen M, Moorthy A, Cato AC. DUSP1 knockout mice show enhanced susceptibility to anaphylaxis but are sensitive to glucocorticoids. Mol Endocrinol 2007, 21, 2663-71 [PubMed]
  • Kleiman A, Tuckermann JP. Glucocorticoid receptor action in beneficial and side effects of steroid therapy: Lessons from conditional knockout mice. Mol Cell Endocrinol 2007, 275, 98-108 [PubMed]
  • James CG, Ulici V, Tuckermann JP, Underhill TM, Beier F. Expression profiling of Dexamethasone-treated primary chondrocytes identifies targets of glucocorticoid signalling in endochondral bone development. BMC Genomics 2007, 8, 205 [PubMed]
  • Tuckermann, JP, Kleiman A, Moriggl R, Spanbroek R, Neumann A, Illing A, Clausen BE, Stride B, Förster I, Habenicht AJR, Reichardt HM, Tronche F, Schmid W, Schütz G. Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy. J Clin Invest 2007, 117, 1381-90 [PubMed]

    • 2006

  • Abraham SM, Lawrence T, Kleiman A, Warden P, Medghalchi M, Tuckermann JP, Saklatvala J, Clark AR. Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1. J Exp Med 2006, 203, 1883-9 [PubMed]

    • 2005

  • Tuckermann JP, Kleyman A, McPherson KG, Reichardt HM. Molecular mechanisms of glucocorticoids in the control of inflammation and lymphocyte apoptosis. Crit Rev Clin Lab Sci 2005, 42, 71-104 [PubMed]

    • 2004

  • Lee YN, Tuckermann JP, Nechushtan H, Schütz G, Razin E, Angel P. c-Fos as a regulator of degranulation and cytokine production in FcepsilonRI-activated mast cells. J Immunol 2004, 173, 2571-7 [PubMed]

    • 2003

  • Bierbaum H, Baumann S, Herr I, Tuckermann JP, Hess J, Schorpp-Kistner M, Angel P. Early activation and induction of apoptosis in T cells is independent of c-Fos. Ann N Y Acad Sci 2003, 1010, 225-31 [PubMed]

    • 2002

  • Limbourg FP, Huang Z, Plumier JC, Simoncini T, Fujioka M, Tuckermann JP, Schütz G, Moskowitz MA, Liao JK. Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids. J Clin Invest 2002, 110, 1729-38 [PubMed]
  • Grose R, Werner S, Kessler D, Tuckermann JP, Huggel K, Durka S, Reichardt HM, Werner S. A role for endogenous glucocorticoids in wound repair. EMBO Rep 2002, 3, 575-82 [PubMed]
  • Gebhardt C, Breitenbach U, Tuckermann JP, Dittrich BT, Richter KH, Angel P. Calgranulins S100A8 and S100A9 are negatively regulated by glucocorticoids in a c-Fos-dependent manner and overexpressed throughout skin carcinogenesis. Oncogene 2002, 21, 4266-76 [PubMed]
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    2001

  • Reichardt HM, Tuckermann JP, Göttlicher M, Vujic M, Weih F, Angel P, Herrlich P, Schütz G. Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor. EMBO J 2001, 20, 7168-73.[PubMed]
  • Tuckermann JP, Vallon R, Gack S, Grigoriadis AE, Porte D, Lutz A, Wagner EF, Schmidt J, Angel P. Expression of collagenase-3 (MMP-13) in c-fos-induced osteosarcomas and chondrosarcomas is restricted to a subset of cells of the osteo-/chondrogenic lineage. Differentiation 2001, 69, 49-57.[PubMed]
  • Breitenbach U, Tuckermann JP, Gebhardt C, Richter KH, Fürstenberger G, Christofori G, Angel P. Keratinocyte-specific onset of serine protease BSSP expression in experimental carcinogenesis. J Invest Dermatol 2001, 117, 634-40.[PubMed]
  • Labrador JP, Azcoitia V, Tuckermann PJ, Lin C, Olaso E, Mañes S, Brückner K, Goergen JL, Lemke G, Yancopoulos G, Angel P, Martínez C, Klein R. The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep 2001, 2, 446-52.[PubMed]

    • 2000

  • Tuckermann JP, Pittois K, Partridge NC, Merregaert J, Angel P. Collagenase-3 (MMP-13) and integral membrane protein 2a (Itm2a) are marker genes of chondrogenic/osteoblastic cells in bone formation: sequential temporal, and spatial expresssioin of Itm2a, alkaline phosphatase, MMP-13, and osteocalcin in the mouse. J Bone Miner Res 2000, 15, 1257-65.[PubMed]

    • 1999

  • Reichardt HM, Tuckermann JP, Bauer A, Schütz G. Molecular genetic dissection of glucocorticoid receptor function in vivo. Z Rheumatol 2000, 59 Suppl 2, II/1-5.[PubMed]
  • Tuckermann JP, Reichardt HM, Arribas R, Richter KH, Schütz G, Angel P. The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin. J Cell Biol 1999, 147, 1365-70.[PubMed]
  • Porte D, Tuckermann JP, Becker M, Baumann B, Teurich S, Higgins T, Owen MJ, Schorpp-Kistner M, Angel P. Both AP-1 and Cbfa1-like factors are required for the induction of interstitial collagenase by parathyroid hormone. Oncogene 1999, 18, 667-78.[PubMed]

    • 1998

  • Reichardt HM, Kästner KH, Tuckermann JP, Kretz O, Wessely O, Bock R, Gass P, Schmid W, Herrlich P, Angel P, Schütz G. DNA binding of the glucocorticoid receptor is not essential for survival. Cell 1998, 93, 531-41.[PubMed]
  • Reuter A, Nestl A, Zwacka RM, Tuckermann JP, Waldherr R, Wagner EM, Höyhtyä M, Meyer zum Gottesberge AM, Angel P, Weiher H. Expression of the recessive glomerulosclerosis gene Mpv17 regulates MMP-2 expression in fibroblasts, the kidney, and the inner ear of mice. Mol Biol Cell 1998, 9, 1675-82.[PubMed]

    • 1997

    1996

    1995

  • Gack S, Vallon R, Schmidt J, Grigoriadis A, Tuckermann JP, Schenkel J, Weiher H, Wagner EF, Angel P. Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes. Cell Growth Differ 1995, 6, 759-67.[PubMed]

 

Buchkapitel

  • Tuckermann JP, Herrlich P. Transcriptional Regulation. In: Encyclopedia of Molecular Pharmacology, 2nd ed. (eds. Offermanns S & Rosenthal W). Springer, New York, USA, 2008. XXVII, 1505 p., 487 illus.

 

Patente

  • Angel P, Tuckermann J, Reichardt H, Schütz G. 26.7.2001 Non-human mammal with a modified glucocorticoid receptor and a modified C-FOS. DE10001975 A
  • Angel P, Breitenbach U., Richter H, Hess J, Tuckermann JP, Fürstenberger G. 17.12.2001. Cloning of a cDNA of the tumor associated gene TAP-70. EP02006089.9
  • Herrlich P, Reichardt H., Schütz G, Kästner K, Angel P, Tuckermann JP. 16.09.1999. Non-human transgenic mammal, method for producing same and its use. DE19815958

 

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