Publikationen Manuel E. Than

  • Creemers J, Choquet H, Stijnen P, Vatin V, Pigeyre M, Beckers S, Meulemans S, Than ME, Yengo L, Tauber M, Balkau B, Elliott P, Jarvelin M-R, Van Hul W, Van Gaal L, Hoberl F, Pattoul F, Froguel P, Meyre D. Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity. Diabetes 2012, 61, 383-390 [PubMed]
  • Dahms SO, Könnig I, Roeser D, Gührs KH, Mayer MC, Kaden D, Multhaup G, Than ME. Metal binding dictates conformation and function of the Amyloid Precursor Protein (APP) E2 domain. J Mol Biol 2012, 416, 438-452 [PubMed]
  • Kuester M, Becker GL, Hardes K, Lindberg I, Steinmetzer T, Than ME. Purification of the proprotein convertase furin by affinity chromatography based on PC-specific inhibitors. Biol Chem 2011, 392, 973-981 [PubMed]
  • Kuester M, Kemmerzehl S, Dahms SO, Roeser D, Than ME. The crystal structure of death receptor 6 (DR6): A potential receptor of the amyloid precursor protein (APP). J Mol Biol 2011, 409, 189-201 [PubMed]
  • Sielaff F, Than ME, Bevec D, Lindberg I, Steinmetzer T. New furin inhibitors based on weakly basic amidinohydrazones. Bioorg Med Chem Lett. 2011, 21, 836-840 [PubMed]
  • Dislich B, Than ME, Lichtenthaler SF. Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33. Biochem J 2010, 433, 75-83 [PubMed]
  • Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C. ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import. EMBO J 2010, 29, 2841-2857 [PubMed] EMBO review
  • Dahms SO, Hoefgen S, Roeser D, Schlott B, Gührs KH, Than ME. Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein. Proc Natl Acad Sci USA. 2010, 107, 5381-5386 [PubMed]
  • Becker GL, Sielaff F, Than ME, Lindberg I, Routhier S, Day R, Lu Y, Garten W, Steinmetzer T. Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J Med Chem. 2010, 53, 1067-1075 [PubMed]
  • Keil C, Maskos K, Than ME, Hoopes JT, Huber R, Tan F, Deddish PA, Erdös EG, Skidgel RA, Bode W. Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain. J Mol Biol 2007, 366, 504-516 [PubMed]
  • Than ME. Structure, Function, and Inhibition of the Prohormone/Proprotein Convertase Family of Endoproteinases. Habilitationsschrift, LMU München 2006 [PDF (87MB)]
  • Steiner H, Than ME, Bode W, Haass C. Pore-forming scissors? A first structural glimpse of gamma-secretase. Trends Biochem Sci 2006, 31, 491-493 [PubMed]
  • Steinmetzer T, Schweinitz A, Stürzenbecher A, Dönnecke D, Uhland K, Schuster O, Steinmetzer P, Friedrich R, Than ME, Bode W, Stürzebecher J. Secondary amides of sulfonylated 3-amidinophenylalanine - New Potent and selective inhibitors of matriptase. J Med Chem 2006, 49, 4116-426 [PubMed]
  • Rohr KB, Selwood T, Marquardt U, Huber R, Schechter NM, Bode W, Than ME. X-ray Structures of Free and Leupeptin-Complexed Human αI-Tryptase Mutants: Indication for an α->β-Tryptase Transition. J Mol Biol 2006, 357, 195-209 [PubMed]
  • Kacprzak MM, Than ME, Juliano L, Juliano MA, Bode W, Lindberg I. Mutations of the PC2 substrate binding pocket alter enzyme specificity. J Biol Chem 2005, 280, 31850-31858 [PubMed]
  • Than ME, Bourenkov G. P, Henrich S. Mann K, Bode W. The NC1 dimer of human placental basement membrane collagen IV: Does a covalent crosslink exist? Biol Chem 2005, 386, 759-766 [PubMed]
  • Than ME, Henrich S, Bourenkov G. P, Bartunik HD, Huber R, Bode W. The endoproteinase furin contains two essential Ca2+ ions stabilizing its N-terminus and the unique S1-specificity pocket. Acta Cryst 2005, D61, 505-512 [PubMed]
  • Henrich S, Lindberg I, Bode W, Than ME. Proprotein Convertase Models based on the Crystal Structures of Furin and Kexin: Explanation of their Specificity. J Mol Biol 2005, 345, 211-227 [PubMed]
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  • Keil C, Huber R, Bode W, Than ME. Cloning, expression, crystallization and initial crystallographic analysis of the C-terminal domain of the amyloid precursor protein APP. Acta Cryst 2004, D60, 1614-1617 [PubMed]
  • Kacprzak MM, Peinado J. R, Than ME, Appel J, Henrich S, Lipkind G, Houghten RA, Bode W, Lindberg I (2004). Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine. J Biol Chem 2004, 279, 36788-36794 [PubMed]
  • Than ME, Helm M, Simpson DJ, Lottspeich F, Huber R, Gietl C. The 2.0 Å crystal structure and substrate specificity of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm. J Mol Biol 2004, 336, 1103-1116 [PubMed]
  • Henrich S, Cameron A, Bourenkov GP, Kiefersauer R, Huber R, Lindberg I, Bode W, Than ME. The crystal structure of the proprotein processing proteinase furin explains its stringent specificity. Nat Struct Biol 2003, 10, 520-526 [PubMed]
  • Than ME, Henrich S, Huber R, Ries A, Mann K, Kühn K, Timpl R, Bourenkov GP, Bartunik HD, Bode W. The 1.9 Å crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link. Proc Natl Acad Sci U S A 2002, 99, 6607-6612 [PubMed]
  • Soulimane T, Kierfersauer R, Than ME. ba3-Type Cytochrome-c Oxidase from Thermus thermophilus: Purification, Crystallization and Crystal Transformation. in: Hunte C, Schägger H, von Jagow G (eds.) Membrane Protein Purification and Crystallization. 2nd ed. Academic Press, 2002, pp. 229-251
  • Than ME, Soulimane T. ba3-cytochrome c oxidase from Thermus thermophilus. in: Messerschmidt A, Huber R, Poulos T, Wieghardt K (eds.) Handbook of Metalloproteins. John Wiley & Sons, Chichester 2001, pp. 363-378
  • Than ME. Röntgenstrukturanalyse der ba3 Cytochrom-c Oxidase aus Thermus thermophilus und ihres Substrates Cytochrom-c552. Ph.D. Thesis, TU München 2000
  • Soulimane T, Than ME, Dewor M, Huber R, Buse G. Primary structure of a novel subunit in ba3-cytochrome oxidase from Thermus thermophilus. Prot Sci 2000, 9, 2068-2073 [PubMed]
  • Soulimane T, Buse G, Bourenkov GP, Bartunik HD, Huber R, Than ME. Structure and Mechanism of the Aberrant ba3-Cytochrome c Oxidase from Thermus thermophilus. EMBO J 2000, 19, 1766-1776 [PubMed]
  • Kiefersauer R, Than, ME, Dobbek H, Gremer L, Melero M, Strobl S, Dias JM, Soulimane T, Huber R. A novel free-mounting system for protein crystals: transformation and improvement of diffraction power by accurately controlled humidity changes. J Appl Crystallogr 2000, 33, 1223-1230
  • Dias JM, Than ME, Humm A, Huber R, Bourenkov GP, Bartunik HD, Bursakov S, Calvete J, Caldeira J, Carneiro C, Moura JJG, Moura I, Romao MJ. Crystal Structure of the first Dissimilatory Nitrate Reductase (NAP) at 1.9 Å solved by MAD methods. Structure 1999, 7, 65-79 [PubMed]
  • Reuter W, Wiegand G, Huber R, Than ME. Structural analysis at 2.2 Å of orthorhombic crystals presents the asymmetry of the allophycocyanin-linker complex, AP.LC7.8, from phycobilisomes of Mastigocladus laminosus. Proc Natl Acad Sci U S A 1999, 96, 1363-1368 [PubMed]
  • Schnackenberg J, Than ME, Mann K, Wiegand G, Huber R, Reuter W. Amino Acid Sequence, Crystallization and Structure Determination of Reduced and Oxydized Cytochrome c6 from the Green Alga Scenedesmus obliquus. J Mol Biol 1999, 290, 1019-1030 [PubMed]
  • Soulimane T, von Walter M, Hof P, Than ME, Huber R, Buse G. Cytochrome-c552 from Thermus thermophilus: A functional and crystallographic investigation. Biochem Biophys Res Commun 1997, 237, 572-576 [PubMed]
  • Than ME, Hof P, Huber R, Bourenkov GP, Bartunik HD, Buse G, Soulimane T. Thermus thermophilus cytochrome-c552: a new highly thermostable cytochrome-c structure obtained by MAD phasing. J Mol Biol 1997, 271, 629-664 [PubMed]
  • Than ME. Photoaffinity Labelling of the active site of DNA-Polymerases. Masters Thesis, University of Delaware 1996

 

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