Platzer Laboratory

Genome analysis

Genomics of ageing, complex diseases, and model organisms

Projects (selected)

» The "genealogical tree" of Ernst Haeckel (1874).

• Towards a novel model for ageing research: genome analysis of the short-lived seasonal fish Nothobranchius furzeri » more
• Investigating natural ways to exceptional long healthspan - the mole-rat case » more
• Mild stress in healthy ageing - comparative transcriptomics within the Jena centre of systems biology of ageing » JenAge
• Impact of genomic variations and DNA methylation on human longevity, ageing of the brain (EU/BrainAGE) and obesity » more
• Genetic predisposition to environmental and age-related disorders (inflammatory bowel disease, sepsis [SEPTOMICS / CSCC], psoriasis) with special emphasis on copy-number and sequence variations of human defensin genes
• Providing genomic expertise for collaborative projects: Exploring the Triticeae genomes by next-generation sequencing (BARLEX / TRITEX); Olfactory mate choice among bats and hyenas (PAKT / IZW)
• Development of bioinformatics approaches for assembly and repeat annotation of complex genomes (Klaus Tschira Foundation) and their transcriptomes » more

Recent selected publications

• Heidel A, Lawal H, Felder M, Schilde C, Helps N, Tunggal B, Rivero F, John U, Schleicher M, Eichinger L, Platzer M, Noegel A, Schaap P, Glöckner G. Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication. Genome Res, 2011. [Sep 15. Epub ahead of print]
• Mayer K F, Martis M, Hedley P E, Simkova H, Liu H, Morris J A, Steuernagel B, Taudien S, Roessner S, Gundlach H, Kubalakova M, Suchankova P, Murat F, Felder M, Nussbaumer T, Graner A, Salse J, Endo T, Sakai H, Tanaka T, Itoh T, Sato K, Platzer M, Matsumoto T, Scholz U, Dolezel J, Waugh R, Stein N. Unlocking the Barley Genome by Chromosomal and Comparative Genomics. Plant Cell 2011, 23, 1249-1263. [PubMed]
• Groth M, Wiegand C, Szafranski K, Huse K, Kramer M, Rosenstiel P, Schreiber S, Norgauer J, Platzer M. Both copy number and sequence variations affect expression of human DEFB4. Genes Immun 2010, 11, 458-466. [PubMed]
• Reichwald K, Lauber C, Nanda I, Kirschner J, Hartmann N, Schories S, Gausmann U, Taudien S, Schilhabel M B, Szafranski K, Glockner G, Schmid M, Cellerino A, Schartl M, Englert C, Platzer M (2009) High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research. Genome Biol, 10, R16. [PubMed]
• Siddiqui R A, Sauermann U, Altmuller J, Fritzer E, Nothnagel M, Dalibor N, Fellay J, Kaup F J, Stahl-Hennig C, Nurnberg P, Krawczak M, Platzer M. (2009) X chromosomal variation is associated with slow progression to AIDS in HIV-1-infected women. Am J Hum Genet 2009, 85, 228-239. [PubMed]