Forschungsgruppe Greulich

Einzelheiten siehe hier auf den Seiten der Gruppe

Ausgewählte Publikationen

• Kuhnert A, Schmidt U, Monajembashi S, Franke C, Schlott B, Grosse F, Greulich KO, Saluz HP, Hänel F (2011) Proteomic identification of a PSF/p54(nrb) heterodimer as TopBP1-interacting proteins: impact on recognition of damaged DNA. J Cell Bioch, submitted.
• Grigaravicius P, Lenser T, Monajembashi S, Wang ZQ, Greulich KO (2011) Late choice between non-homologous end joining and homologous recombination repair after DNA damage induction by a laser-microbeam. Nucl Acids Res, in revision.
• Jahns F, Wilhelm A, Greulich KO, Mothes H, Radeva M, Wölfert A, Glei M (2011) Impact of butyrate on PKM2 and HSP90ß expression in human colon tissues of different transformation stages. A comparison of gene and protein data. Genes and Nutrition, in revision.
• Wilhelm A, Jahns F, Böcker S, Mothes H, Greulich KO, Glei M (2011) Improvement of primary non-transformed human colon epithelial cell culture by using colon crypts. Toxicol in Vitro, in revision.
• Greulich KO (2011) Single DNA molecule typing, heart beating, DNA repair and ageing: The contribution of fluorescence techniques. Ann Rev Fluor, in press.
• Radeva M, Jahns F, Wilhelm A, Glei M, Settmacher U, Greulich, KO and Mothes, H (2010) Defensin alpha 6 (DEFA 6) overexpression threshold of over 60 fold can distinguish between adenoma and fully blown colon carcinoma in individual patients. BMC Cancer, 10, 588-593. [biomedcentral.com ]
• Altenberg B, Greulich KO (2011) Laser microbeam – kinetic studies combined with molecule – structures reveal mechanisms of DNA repair. Proc SPIE 8097, doi:10.1117/12.893652.
• Jahns F, Wilhelm A, Jablonowski N, Mothes H, Radeva M, Wölfert A, Greulich KO, Glei M (2011) Butyrate suppresses mRNA increase of osteopontin and cyclooxygenase-2 in human colon tumor tissue. Carcinogenesis 32, 913-920.
• Greulich KO (2011) Photons bring light into DNA repair: The comet assay and laser microbeams for studying photo – genotoxicity of drugs and ageing. J Biophot, 4, 165-171.
• Greulich KO (2010) Optical Tweezers. Encyclopedia of Life Sciences. Elsevier, doi: 10.1002/9780470015902.a0003038.pub2.
• Greulich KO (2010) Single molecule experiments challenge the strict wave particle dualism of light. Int. J Mol Sci, 11, 304-311.
• Greulich KO (2010) Calculation of the masses of all fundamental elementary particles with an accuracy of approx. 1%. J Mod Phys, 1, 300-302.
• Dreblow K, Kalchishkova N, Böhm KJ (2010) Kinesin passing permanent blockages along its protofilament track. Biochem Biophys Res Commun, 395, 490-495. [PubMed]
• Prinz H, Böhm KJ, Müller K (2010) Synthesis of 2,6-aceanthrylenedione, a cyclic vinylog of anthraquinone. J Org Chem , 75, 3867-3870. [PubMed]
• Surkau G, Böhm KJ, Müller K, Prinz H (2010) Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives. Eur J Med Chem , 45, 3354-3364. [PubMed]
• Nickel HC, Schmidt P, Böhm KJ, Baasner S, Müller K, Gerlach M, Unger E, Günther EG, Prinz H (2010) Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety. Eur J Med Chem , 45, 3420-3438. [PubMed]
• Dráberová E, Sulimenko V, Sulimenko T, Böhm KJ, Dráber P (2010) Recovery of tubulin functions after freeze-drying in the presence of trehalose. Anal Biochem, 397, 67-72. [PubMed]
• Prinz H, Schmidt P, Böhm KJ, Baasner S, Müller K, Unger E, Gerlach M, Günther EG (2009) 10-Phenyl-(2-oxo-ethylidene)-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem, 52, 1284-1294. [PubMed]
• Grigaravicius P, Greulich KO, Monajembashi S (2009) Laser Microbeams and Optical Tweezers in Ageing Research. ChemPhysChem, 10, 79-85. [PubMed]
• Grigaravicius P, Rapp A, Greulich KO (2009) A direct view by immunofluorescent comet assay (IFCA) of DNA damage induced by nicking and cutting enzymes, ionizing 137 Cs radiation, UV A laser microbeam irradiation and the radiomimetic drug bleomycin. Mutagenesis, 24, 191-197. [PubMed]
• Prinz H, Schmidt P, Böhm KJ, Baasner S, Müller K, Unger E, Gerlach M, Günther EG (2009) 10-Phenyl-(2-oxo-ethylidene)-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem, 52, 1284-1294. [PubMed]
• Kalchishkova N, Böhm KJ (2008) The role of kinesin neck linker and neck in velocity regulation. J Mol Biol, 382, 127-135. [PubMed]
• Greulich KO (2008) The wave property of heavy molecules - Its use in mass spectrometry. Angew Chem Int Ed Engl, 47, 7990-7991. [PubMed]
• Berns MW, Greulich KO (Eds) Laser Manipulation of Cells and Tissue. Methods in Cell Biology. (2007) Vol 82, Elsevier, Academic Press. [Amazon]
• Altenberg B, Gemuend C, Greulich KO (2006) Ubiquitous cancer genes: multipurpose molecules for protein micro-arrays. Proteomics, 6, 67-71. [PubMed]
• Altenberg B, Greulich KO (2004) Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. Genomics, 84, 1014-1020. [PubMed]
• Rapp A, Greulich KO (2004) After double-strand break induction by UV-A, homologous recombination and nonhomologous end joining cooperate at the same DSB if both systems are available. J Cell Sci, 117, 4935-4945. [PubMed]
• Behrens S, Rahn K, Habicht W, Böhm KJ, Rösner H, Dinjus E, Unger E (2002) Nanoscale particle arrays induced by highly ordered protein assemblies. Adv Materials, 14, 1621-1625.
• Rapp A, Bock C, Dittmar H, Greulich KO (2000) UV-A breakage sensitivity of human chromosomes measured by COMET-FISH depends on gene density and not on the chromosome size. J Photochem Photobiol B, 56, 109-117. [PubMed]
• Greulich KO (Ed) Micromanipulation by Light in Biology and Medicine: the Laser Microbeam and Optical Tweezers. Methods in Bioengineering (1999), Birkhäuser Boston. [Amazon]